warning icon
YOUR BROWSER IS OUT OF DATE!

This website uses the latest web technologies so it requires an up-to-date, fast browser!
Please try Firefox or Chrome!

Cialis and GrapefruitsDoctors usually advise against consuming grapefruit or its products while on Cialis due to how the two substances interact. Taking the erectile dysfunction (ED) medication together with Cialis can even raise the risk of side effects. All Cialis prescriptions carry this warning that the drug should not be combined with grapefruit. If you are someone who consumes a lot of grapefruit on a regular basis, it is important to discuss this with the healthcare provider if you are required to take Cialis for ED. The effectiveness of Cialis can be reduced and it may not help overcome ED when grapefruit is consumed due to the reduced efficacy of the medication. Read on to find out more about how grapefruit affects the properties of Cialis and what adverse reactions can occur.

How does grapefruit affect the metabolism of Cialis?

Grapefruit and Cialis are not recommended for simultaneous consumption due to how they affect the metabolism of the erectile dysfunction drug. By breaking the details of what exactly happens one can easily understand the adverse effects. Grapefruit contains certain enzymes that are known to interact with the enzyme present in the liver and intestines called CYP 3A4, which is important for the body’s metabolism of certain drugs like Cialis. CYP 3A4 helps regulate how much of the drug is absorbed into the system. The consumption of grapefruit can delay the effects of Cialis and the drug may also last longer in the system.

The reason why this is a problem is that Cialis already has very less bioavailability. Hence, the dosage of Cialis is formulated for it to be effective even with the reduced absorption rate. Based on your body’s response to the medication and how it reacts to grapefruit, you may either feel reduced efficacy in getting an erection or too much of the drug being absorbed into the system at once.

What are the effects of Cialis and grapefruit interaction?

Some of the side effects that can be expected with Cialis and grapefruit interaction are:

  • Upset stomach
  • Headache
  • Drowsiness
  • Nausea
  • Dizziness

Increased levels of Cialis in the blood can also result in drug overdose, which can lead to problems like stroke, heart problems and brain damage. Even if you take Cialis only on an as-needed basis for ED, it is important to take suitable precautions to avoid interactions with grapefruit. The enzymes present in grapefruit can remain in the digestive system for up to 72 hours. Likewise, Cialis also has longer lasting effects. If you must have grapefruit or any products containing it, be sure to let a few days pass before taking the drug. Look out for any side effects and get them addressed before they lead to any additional health problems.

loading
×