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Product Description

Trental is the generic formulation of Pentoxifylline, a Xanthine derivative. The muscle pain reliever works by relaxing the red blood cells to improve the blood flow.

Trental has an active half-life of about one to one and a half hours.


Trental is predominantly used to treat peripheral artery disease, where the patient diagnosed with this condition experiences intermittent pain in the muscles, strains, or cramping, especially while walking or doing other such activities.

Trental may also be prescribed for other health problems which may benefit from the therapeutic effects of Pentoxifylline.


The typical dosage of Trental is 400 mg, which may be prescribed for taking multiple times in a day based on the patient’s diagnosis.

Trental is best taken exactly as prescribed by the healthcare provider. One can also read the instructions of the on the product label.

The orally ingested Trental tablets should be swallowed whole without breaking, crushing, or chewing them. The compressed tablet is taken with a meal. The medication course should be completed fully even if the symptoms have improved before the course is over.

Do not double the dose or take two doses of Trental close together if the dose is missed, but skip the missed dose. The medication therapy may be required for two to four weeks for complete recovery, after which the dose should not be continued without the doctor’s recommendation.

Important safety information

Precaution is required if someone is using blood pressure medications, over-the-counter pills, vitamins, herbal supplements, dietary pills, anticoagulants, Ciprofloxacin, and Theophylline while on Trental. For any clarifications on safety of medication use, the healthcare professional would be able to provide the required information.

Certain health conditions can decrease the effectiveness of Trental and can also cause harmful effects. The individual should disclose to the physician of he or she has any allergies, stomach ailments, ulcers, blood vessel issues, blood pressure troubles, liver problems or kidney diseases.

Trental is not indicated for use in persons who are allergic to the active ingredient or had a bleeding disorder in the brain or eye.

Lactating women should not take Trental as it can pass through breast milk and harm the baby. In case of pregnancy, inform the doctor immediately and get suitable assistance on whether to continue with the medication or not.

Side Effects

Mild side effects like flushing, gas troubles, flatulence, upset stomach, nausea, dizziness, and vomiting may occur from taking Trental. For any allergic reactions or more persistent side effects, seek emergency medical assistance