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Product Description

Ponstel is the brand name of mefenamic acid that belongs to a class of nonsteroidal anti-inflammatory drugs (NSAID). It works by inhibiting both constitutive isoform and inducible isoform of cyclooxygenase (COX) and prevents the generation of prostaglandins. The prostaglandins belong to a group of physiologically active lipids that are found in every tissue of human beings. As part of a group of anthranilic acid derivatives the medication is effectively utilized in the treatment of mild to moderate pain. This medication was approved by FDA in the year 1967 for use in US markets.


Ponstel is mainly used to relieve pain that arises during menstruation. It can also be used to treat migraine headaches associated with menstruation. But in that case, it should be taken at least a day prior to the onset of headache which arises during menstruation.

Ponstel also helps to treat pain that is caused due to arthritis. Due to its severity in increasing the risk of heart stroke or life threatening problems the medication is not utilized widely.


Ponstel is available in many dosage strengths out of which 500 mg is the recommended dosage for the treatment of acute pain in adults and also in children above 14 years.

The initial dose is followed by 250mg if needed.

The second dose of Ponstel has to be taken only after 6 hours upon taking the initial dose.

Ponstel can be taken with food and the dosage of the medication remains the same when it is taken to help in the treatment of people with primary dysmenorrhea (pain that occurs in the lower abdomen during menstruation).

Side Effects

Common side effects like vomiting, nervousness, headaches, depression and shivering may occur and subside on completion of menstruation. One should seek immediate medical help when they experience the below side effects.

When a person taking Ponstel experiences any of the above side effects, he/she is supposed to stop taking the medication and get treated by her physician immediately to avoid unwanted consequences. These side effects may happen when the medication is taken for prolonged or shorter duration of time than scheduled.

Safety information

While taking Ponstel, the person is advised not to take any over-the-counter antibiotics or pain relief medications without consulting their physician as it may interact with the medicine. Also the patient is supposed to inform his physician when he takes antidepressants like fluoxetine or paroxetine together with this medication.

People having asthma, liver diseases, blood ailments and gastrointestinal problems should be extremely careful while using Ponstel.